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1

Structural Bioinformatics-Based Prediction of Exceptional Selectivity of p38 MAP Kinase Inhibitor PH-797804

Xing, Li, Shieh, Huey S., Selness, Shaun R., Devraj, Rajesh V., Walker, John K., Devadas, Balekudru, Hope, Heidi R., Compton, Robert P., Schindler, John F., Hirsch, Jeffrey L., Benson, Alan G., Kurumb

Journal:

Year:

2009

Language:

english

File:

PDF, 4.34 MB

english, 2009

2

Selective peptidic and peptidomimetic inhibitors of Candida albicans myristoylCoA: Protein N-myristoyltransferase: A new approach to antifungal therapy

James A. Sikorski, Balekudru Devadas, Mark E. Zupec, Sandra K. Freeman, David L. Brown, Hwang-Fun Lu, Srinivasan Nagarajan, Pramod P. Mehta, Arlene C. Wade, Nandini S. Kishore, Martin L. Bryant, Danie

Journal:

Year:

1997

Language:

english

File:

PDF, 474 KB

english, 1997

3

ChemInform Abstract: Substituted N-Aryl-6-pyrimidinones: A New Class of Potent, Selective, and Orally Active p38 MAP Kinase Inhibitors.

Balekudru Devadas, et al. et al.

Journal:

Year:

2011

File:

PDF, 22 KB

2011

4

Synthesis of novel tritium labeled oxamyristic acids

Balekudru Devadas, Steven P. Adams, Jeffrey I. Gordon

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1991

Language:

english

File:

PDF, 303 KB

english, 1991

5

6-Nitro-1-β-napthalenesulfonyloxybenzotriazole : A novel coupling reagent for peptide synthesis

Balekudru Devadas, Bijoy Kundu, Alka Srivastava, Krishna B Mathur

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 145 KB

english, 1993

6

A chiral recognition element with an unusual size constraint affects the potency and selectivity for peptidomimetic inhibitors of Candida albicans myristoyl-CoA:protein N-myristoyltransferase

Balekudru Devadas, Sandra K. Freeman, Charles A. McWherter, David W. Kuneman, Dutt V. Vinjamoori, James A. Sikorski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 266 KB

english, 1996

7

R-Isomers of Arg-Gly-Asp (RGD) mimics as potent αvβ3 inhibitors

Srinivasan R. Nagarajan, Balekudru Devadas, James W. Malecha, Hwang-Fun Lu, Peter G. Ruminski, Joseph G. Rico, Thomas E. Rogers, Laura D. Marrufo, Joe T. Collins, H. Peter Kleine, Melissa K. Lantz, Ju

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 404 KB

english, 2007

8

Discovery of N-substituted pyridinones as potent and selective inhibitors of p38 kinase

Shaun R. Selness, Rajesh V. Devraj, Joseph B. Monahan, Terri L. Boehm, John K. Walker, Balekudru Devadas, Richard C. Durley, Ravi Kurumbail, Huey Shieh, Li Xing, Michael Hepperle, Paul V. Rucker, Kevi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 394 KB

english, 2009

9

Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase

Shaun R. Selness, Rajesh V. Devraj, Balekudru Devadas, John K. Walker, Terri L. Boehm, Richard C. Durley, Huey Shieh, Li Xing, Paul V. Rucker, Kevin D. Jerome, Alan G. Benson, Laura D. Marrufo, Heathe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 570 KB

english, 2011

10

Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase

Shaun R. Selness, Terri L. Boehm, John K. Walker, Balekudru Devadas, Richard C. Durley, Ravi Kurumbail, Huey Shieh, Li Xing, Michael Hepperle, Paul V. Rucker, Kevin D. Jerome, Alan G. Benson, Laura D.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 689 KB

english, 2011

11

Substituted N-aryl-6-pyrimidinones: A new class of potent, selective, and orally active p38 MAP kinase inhibitors

Balekudru Devadas, Shaun R. Selness, Li Xing, Heather M. Madsen, Laura D. Marrufo, Huey Shieh, Dean M. Messing, Jerry Z. Yang, Heidi M. Morgan, Gary D. Anderson, Elizabeth G. Webb, Jian Zhang, Rajesh

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 466 KB

english, 2011

12

The synthesis of spiro and bicyclic nucleosides from ribose adducts of diahinomaleonitrile

James P. Ferris, Balekudru Devadas

Journal:

Tetrahedron Letters

Year:

1986

Language:

english

File:

PDF, 205 KB

english, 1986

13

Synthesis of myristic acid analogs with anti-HIV activity that may be resistant to metabolic processing by β-oxidation

Balekudru Devadas, Nandini S. Kishore, Steven P. Adams, Jeffrey I. Gordon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 400 KB

english, 1993

14

Replacements for lysine in l-seryl-l-lysyl dipeptide amide inhibitors of candida albicans myristoyl-CoA:protein N-myristoyltransferase

David L. Brown, Balekudru Devadas, Hwang-Fun Lu, Srinivasan Nagarajan, Mark E. Zupec, Sandra K. Freeman, Charles A. McWherter, Daniel P. Getman, James A. Sikorski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 225 KB

english, 1997

15

Discovery and Characterization of Atropisomer PH-797804, a p38 MAP Kinase Inhibitor, as a Clinical Drug Candidate

Dr. Li Xing, Dr. Balekudru Devadas, Dr. Rajesh V. Devraj, Dr. Shaun R. Selness, Dr. Huey Shieh, Dr. John K. Walker, Dr. Michael Mao, Dean Messing, Brian Samas, Dr. Jerry Z. Yang, Gary D. Anderson, Eli

Journal:

Year:

2012

Language:

english

File:

PDF, 694 KB

english, 2012

16

Relatives of Watson-Crick DNA, RNA Cross Sections

NELSON J. LEONARD, KENNETH A. CRUICKSHANK, MICHAEL P. GROZIAK, GARY L. CLAUSON, BALEKUDRU DEVADAS

Journal:

Annals of the New York Academy of Sciences

Year:

1986

Language:

english

File:

PDF, 487 KB

english, 1986

17

Design and Synthesis of Novel Imidazole-Substituted Dipeptide Amides as Potent and Selective Inhibitors of Candida albicans MyristoylCoA:Protein N -Myristoyltransferase and Identification of Related Tripeptide Inhibitors with Mechanism-Based Antifungal Activity †

Devadas, Balekudru, Freeman, Sandra K., Zupec, Mark E., Lu, Hwang-Fun, Nagarajan, Srinivasan R., Kishore, Nandini S., Lodge, Jennifer K., Kuneman, David W., McWherter, Charles A., Vinjamoori, Dutt V.,

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 559 KB

english, 1997

18

Synthesis of covalently linked double-helical cross sections representative of purine-pyrimidine, purine-purine, and pyrimidine-pyrimidine duplexes

Devadas, Balekudru, Leonard, Nelson J.

Journal:

Journal of the American Chemical Society

Year:

1990

Language:

english

File:

PDF, 1.48 MB

english, 1990

19

Novel Biologically Active Nonpeptidic Inhibitors of MyristoylCoA:Protein N -Myristoyltransferase

Devadas, Balekudru, Freeman, Sandra K., McWherter, Charles A., Kishore, Nandini S., Lodge, Jennifer K., Jackson-Machelski, Emily, Gordon, Jeffrey I., Sikorski, James A.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 178 KB

english, 1998

20

Design and Syntheses of Potent and Selective Dipeptide Inhibitors of Candida albicans Myristoyl-CoA:Protein N-Myristoyltransferase

Devadas, Balekudru, Zupec, Mark E., Freeman, Sandra K., Brown, David L., Nagarajan, Srinivasan, Sikorski, James A., McWherter, Charles A., Getman, Daniel P., Gordon, Jeffrey I.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 437 KB

english, 1995

21

Synthesis of covalently-linked DNA/RNA cross sections

Devadas, Balekudru., Leonard, Nelson J.

Journal:

Journal of the American Chemical Society

Year:

1986

Language:

english

File:

PDF, 375 KB

english, 1986

22

Conformationally Constrained [ p -(ω-Aminoalkyl)phenacetyl]- l -seryl- l -lysyl Dipeptide Amides as Potent Peptidomimetic Inhibitors of Candida albicans and Human Myristoyl-CoA:Protein N -Myristoyl Transferase

Nagarajan, Srinivasan R., Devadas, Balekudru, Zupec, Mark E., Freeman, Sandra K., Brown, David L., Lu, Hwang-Fun, Mehta, Pramod P., Kishore, Nandini S., McWherter, Charles A., Getman, Daniel P., Gordo

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 797 KB

english, 1997

23

Spiro and bicyclic nucleosides. Preparation of new structural types from ribose adducts of diaminomaleonitrile

Ferris, James P., Devadas, Balekudru

Journal:

Journal of Organic Chemistry

Year:

1987

Language:

english

File:

PDF, 966 KB

english, 1987

24

Titration Calorimetric Analysis of AcylCoA Recognition by MyristoylCoA:Protein N -Myristoyltransferase †

Bhatnagar, Rajiv S., Schall, Otto F., Jackson-Machelski, Emily, Sikorski, James A., Devadas, Balekudru, Gokel, George W., Gordon, Jeffrey I.

Journal:

Year:

1997

Language:

english

File:

PDF, 195 KB

english, 1997

25

Synthesis of covalently-linked double-helical cross sections representative of purine-purine and pyrimidine-pyrimidine duplexes

Leonard, Nelson J., Devadas, Balekudru

Journal:

Journal of the American Chemical Society

Year:

1987

Language:

english

File:

PDF, 415 KB

english, 1987

26

Functional Analysis of Protein N-Myristoylation: Metabolic Labeling Studies Using Three Oxygen-Substituted Analogs of Myristic Acid and Cultured Mammalian Cells Provide Evidence for Protein-Sequence-Specific Incorporation and Analog-Specific Redistribution

D. Russell Johnson, Adrienne D. Cox, Patricia A. Solski, Balekudru Devadas, Steven P. Adams, Richard M. Leimgruber, Robert O. Heuckeroth, Janice E. Buss and Jeffrey I. Gordon

Journal:

Proceedings of the National Academy of Sciences

Year:

1990

Language:

english

File:

PDF, 1.37 MB

english, 1990

27

Syntheses of Novel 3-Substituted-2′-deoxy-3-deazauridine Nucleosides

Devadas, Balekudru, Rogers, Thomas E., Gray, Steven H.

Journal:

Synthetic Communications

Year:

1995

Language:

english

File:

PDF, 426 KB

english, 1995

28

Incorporation of 12-Methoxydodecanoate into the Human Immunodeficiency Virus 1 Gag Polyprotein Precursor Inhibits its Proteolytic Processing and Virus Production in a Chronically Infected Human Lymphoid Cell Line

Martin L. Bryant, Lee Ratner, Robert J. Duronio, Nandini S. Kishore, Balekudru Devadas, Steven P. Adams and Jeffrey I. Gordon

Journal:

Proceedings of the National Academy of Sciences

Year:

1991

File:

PDF, 1.30 MB

1991

29

Incorporation of 12-Methoxydodecanoate into the Human Immunodeficiency Virus 1 Gag Polyprotein Precursor Inhibits its Proteolytic Processing and Virus Production in a Chronically Infected Human Lymphoid Cell Line

Martin L. Bryant, Lee Ratner, Robert J. Duronio, Nandini S. Kishore, Balekudru Devadas, Steven P. Adams and Jeffrey I. Gordon

Journal:

Proceedings of the National Academy of Sciences

Year:

1991

Language:

english

File:

PDF, 1.30 MB

english, 1991